A third man, who has been charged with arson and attempted murder, will appear at Manchester Crown Court on Friday, alongside two others who face similar charges after four siblings aged three to 15 died in a fire on Monday.
Demi Pearson, 15, her brother and sister, Brandon, eight, and Lacie, seven, and three-year-old sister Lia all perished as a result of the devastating blaze which has also left their mother, Michelle, in a coma in hospital unaware of their deaths.
Two 16-year-olds, who cannot be named, managed to escape the fire, which broke out at about 05:00am.
The latest defendant, David Worrall, spoke only to confirm his name, age, nationality and that he had no fixed address. He is accused of four counts of murder, three counts of attempted murder and one count of arson with intent to endanger life.
Mr Worrall joins Mr Bolland and Ms Brierley who have all been remanded in custody until the preliminary hearing on Friday.
Both Mr Bolland and Ms Brierley were due to appear at the crown court on Thursday but their hearing was postponed.